Oct 27, 2022 · Administration advice: This drug should be administered by the intranasal route only. The bottle should be gently shaken before each use. This drug should not be sprayed into the eyes. If sprayed into the eyes, they should be flushed with water for at least 10 minutes. This drug should be primed before initial use by releasing 6 sprays or until ... Aug 3, 2023 · What is azelastine nasal? Azelastine nasal (for the nose) is an antihistamine that is used to treat sneezing, runny or stuffy nose, itching, and other nasal symptoms of allergies. Azelastine nasal is for use in adults and children at least 6 years old. Azelastine nasal may also be used for purposes not listed in this medication guide. dmphoto / Getty Images. It is generally considered safe to use both Flonase and azelastine for the treatment of your allergic rhinitis. Your healthcare provider may recommend this or prescribe you Dymista (azelastine hydrochloride and fluticasone propionate), a nasal spray composed of generic forms of both medications.The only combination treatment, which comprises azelastine hydrochloride and fluticasone propionate, so far in a single advanced delivery system has proven its efficacy and safety in clinical trials of adult patients with AR. Objective: To critically review and identify gaps in the existing data for children in all different strata of pediatric ...This medicine may increase your risk of having some unwanted effects in the nose. Check with your doctor right away if you or your child have bloody mucus, sores inside the nose, unexplained nosebleeds, or a whistling sound when you breathe while you are using this medicine. You may get infections more easily while you are using this medicine.Aug 1, 2023 · Azelastine And Fluticasone (Nasal Route) Azelastine and fluticasone combination nasal spray is used to treat an itchy or runny nose, sneezing, or other symptoms caused by seasonal hay fever (allergic rhinitis). Azelastine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Azelastine nasal spray is a histamine blocker that combines with fluticasone, a corticosteroid. This nasal spray treats the symptoms of allergies like sneezing and a runny or stuffy nose. The brand name of this medication is Dymista®. Follow the instructions on the label to spray this medication into your nose as directed. AZELASTINE; FLUTICASONE (a ZEL as teen; floo TIK a sone) treats allergy symptoms such as sneezing, itching, or runny or stuffy nose. It works by blocking histamine, a substance released by the body during an allergic reaction. It also works by decreasing inflammation in the nose, making it easier to breathe.Oct 28, 2022 · Dymista (Azelastine And Fluticasone Nasal) received an overall rating of 10 out of 10 stars from 5 reviews. See what others have said about Dymista (Azelastine And Fluticasone Nasal), including the effectiveness, ease of use and side effects. Active Ingredients: Azelastine hydrochloride; Fluticasone propionate . Dosage Form; Route: Spray, metered; Nasal . Strength: 0.137 mg/spray; 0.05 mg/spray. Recommended Studies: Two options: (1) eight in vitro bioequivalence studies, or (2) six in vitro bioequivalence studies, one in vivo bioequivalence study with AZELASTINE; FLUTICASONE treats allergy symptoms such as sneezing, itching, or runny or stuffy nose. It works by blocking histamine, a substance released by the body during an allergic reaction. It also works by decreasing inflammation in the nose, making it easier to breathe. It is a combination of an antihistamine and a steroid. Nasonex (mometasone furoate monohydrate) Nasal Spray and Dymista (azelastine hydrochloride and fluticasone propionate) are used to treat nasal symptoms such as congestion, sneezing, and runny nose caused by seasonal or year-round allergies. Nasonex Nasal Spray is also used to treat nasal polyps in adults. Nasonex and Dymista both contain steroids.Dec 5, 2022 · Dymista nasal spray contains a combination of azelastine and fluticasone. Azelastine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Fluticasone is a steroid that prevents the release of substances in the body that cause ... Save more on your first fill of azelastine / fluticasone with GoodRx Gold. Start free trial. as low as $13.97 chevron_right. CVS Pharmacy. $155 retail. Save 66%. $ 52.91. Get free savings. Most popular.Prime azelastine hydrochloride and fluticasone propionate nasal spray before initial use by releasing 6 sprays or until a fine mist appears. Repriming (as needed) When azelastine hydrochloride and fluticasone propionate nasal spray has not been used for 14 or more days, reprime with 1 spray or until a fine mist appears. 3 DOSAGE FORMS AND STRENGTHS Background: A fixed-dose combination of intranasal azelastine hydrochloride and fluticasone propionate (MP-AzeFlu) is the most effective treatment of allergic rhinitis, but its onset of action requires further investigation.Compare Dymista (azelastine/fluticasone) 137/50 mcg prices from verified online pharmacies or local U.S. pharmacies. Free coupons for dymista (azelastine/fluticasone). Save more on your first fill of azelastine / fluticasone with GoodRx Gold. Start free trial. as low as $13.97 chevron_right. CVS Pharmacy. $155 retail. Save 66%. $ 52.91. Get free savings. Most popular. Dymista (azelastine hydrochloride and fluticasone propionate) nasal spray, 137 mcg / 50 mcg contains 0.1% solution of azelastine hydrochloride and 0.037% suspension of micronized fluticasone propionate in an isotonic aqueous suspension containing glycerin, microcrystalline cellulose and carboxymethylcellulose sodium, phenylethyl alcohol (2.5 mg/g), edetate disodium, benzalkonium chloride (0.1 ...Fluticasone; Azelastine hydrochloride; Indications and dose For fluticasone with azelastine Moderate to severe seasonal and perennial allergic rhinitis, if monotherapy with antihistamine or corticosteroid is inadequate for fluticasone with azelastine By intranasal administration Astepro (azelastine), which blocks histamine. NasalCrom (cromolyn sodium), which stabilizes mast cells. Antihistamine nasal sprays work quickly — within 15 minutes. Nasalcrom takes longer, providing relief in about 1 to 2 weeks. Both can be used to both treat and prevent symptoms. OTC decongestant nasal spraysBoth of these nasal sprays contain a steroid (e.g., fluticasone or mometasone) and an antihistamine (e.g., azelastine or olopatadine). When compared to steroid nasal sprays, antihistamine nasal sprays might work faster — but antihistamine sprays are not more effective at treating your allergies. However, the combination of medications may be ...Find patient medical information for azelastine-fluticasone-sodium chloride-sod bicarbonate nasal on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ... Flonase (active ingredient – fluticasone propionate) is a nasal spray that is used to treat seasonal allergic rhinitis symptoms, like sneezing, itchy nose, nasal congestion, runny nose, itchy and watery eyes. According to a 2006 study, azelastine has a comparable action as intranasal fluticasone propionate.Pharmacodynamics. Azelastine antagonizes the actions of histamine, resulting in the relief of histamine-mediated allergy symptoms. 2,10,11 Onset of action occurs within 15 minutes with intranasal formulations and as quickly as 3 minutes with ophthalmic solutions. 1 Intranasal formulations have a relatively long-duration of action, with peak effects observed 4-6 hours after the initial dose and ...May 15, 2021 · Azelastine hydrochloride and fluticasone propionate nasal spray is a prescription medicine used to treat symptoms of seasonal allergic rhinitis in people 6 years of age and older. • Azelastine hydrochloride and fluticasone propionate nasal spray may help to reduce your nasal symptoms including stuffy nose, runny nose, itching, and sneezing. AZELASTINE; FLUTICASONE (a ZEL as teen; floo TIK a sone) treats allergy symptoms such as sneezing, itching, or runny or stuffy nose. It works by blocking histamine, a substance released by the body during an allergic reaction. It also works by decreasing inflammation in the nose, making it easier to breathe.Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Dymista® nasal spray in children 6 years of age and older. However, safety and efficacy have not been established in children younger than 6 years of age. GeriatricAzelastine and fluticasone nasal (for the nose) is a combination antihistamine and steroid medication used to treat sneezing, runny or stuffy nose, itching, and other nasal symptoms of allergies. azelastine and fluticasone nasal is for use in adults and children who are at least 6 years old.Jun 30, 2023 · Introduction. MP-AzeFlu Nasal Spray consists of a fixed-dose combination of azelastine hydrochloride (AZE) and fluticasone propionate (FLU) that is used for the relief of symptoms of moderate to severe seasonal (SAR) and perennial allergic rhinitis (PAR). 1,2 Due to different primary mechanisms of action of the individual agents, MP-AzeFlu nasal spray provides greater efficacy than therapy ... Jun 30, 2023 · Introduction. MP-AzeFlu Nasal Spray consists of a fixed-dose combination of azelastine hydrochloride (AZE) and fluticasone propionate (FLU) that is used for the relief of symptoms of moderate to severe seasonal (SAR) and perennial allergic rhinitis (PAR). 1,2 Due to different primary mechanisms of action of the individual agents, MP-AzeFlu nasal spray provides greater efficacy than therapy ... years of age and older who require treatment with both azelastine hydrochloride and fluticasone propionate for symptomatic relief. (1.1) DOSAGE AND ADMINISTRATION •Recommended dos age: 1 spray per nostril twice daily (2.1) •For intranasal use only. (2.2) •Prime before initial use and when it has not been used for 14 or more days. (2.2) Dymista (azelastine hydrochloride and fluticasone propionate) nasal spray, 137 mcg / 50 mcg contains 0.1% solution of azelastine hydrochloride and 0.037% suspension of micronized fluticasone propionate in an isotonic aqueous suspension containing glycerin, microcrystalline cellulose and carboxymethylcellulose sodium, phenylethyl alcohol (2.5 mg/g), edetate disodium, benzalkonium chloride (0.1 ...Azelastine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. Fluticasone is a steroid (cortisone-like medicine). It works by preventing the inflammation that occurs with allergic reactions.The only combination treatment, which comprises azelastine hydrochloride and fluticasone propionate, so far in a single advanced delivery system has proven its efficacy and safety in clinical trials of adult patients with AR. Objective: To critically review and identify gaps in the existing data for children in all different strata of pediatric ...Azelastine (Astepro) is an antihistamine nasal spray that's good for treating seasonal allergies and nose-related allergy symptoms, such as runny or itchy nose. It used to be available by prescription only, but certain strengths of the medication are now also available over the counter (OTC). Reviewed by: Kristianne Hannemann, PharmDFeb 10, 2020 · Canadian labeling: Hypersensitivity to azelastine, fluticasone, or any component of the formulation; untreated fungal, bacterial, or tuberculosis infections of the respiratory tract. Dosage and Administration Dosing: Adult. Seasonal allergic rhinitis: Intranasal: One spray (137 mcg azelastine/50 mcg fluticasone) per nostril twice daily. Dosing ... Azelastine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. Fluticasone is a steroid (cortisone-like medicine). It works by preventing the inflammation that occurs with allergic reactions.Azelastine (Astepro) is an antihistamine nasal spray that's good for treating seasonal allergies and nose-related allergy symptoms, such as runny or itchy nose. It used to be available by prescription only, but certain strengths of the medication are now also available over the counter (OTC). Reviewed by: Kristianne Hannemann, PharmDDymista® Azelastine HCl / Fluticasone Propionate 137 mcg - 50 mcg Spray Nasal Spray Device 120 Doses Meda Pharmaceuticals 00037024523 Dymista (azelastine / fluticasone) is a combination medication containing azelastine and fluticasone. It works well to treat seasonal allergies for adults and children 6 years and older, especially if allergies don't improve with nasal steroid medications alone.AZELASTINE; FLUTICASONE treats allergy symptoms such as sneezing, itching, or runny or stuffy nose.It works by blocking histamine, a substance released by the body during an allergic reaction. 137 μg of azelastine hydrochloride and 50 μg of fluticasone propionate. The dosing regimen is one spray per nostril twice daily, for a total daily dose of 548 μg of azelastine Objective: To compare an azelastine-fluticasone combination nasal spray administered in a single-delivery device with a commercially available azelastine nasal spray and fluticasone nasal spray. Methods: This 14-day, multicenter, randomized, double-blind study was conducted during the Texas mountain cedar season. After a 5-day placebo lead-in ... Dymista (azelastine hydrochloride and fluticasone propionate) nasal spray, 137 mcg / 50 mcg contains 0.1% solution of azelastine hydrochloride and 0.037% suspension of micronized fluticasone propionate in an isotonic aqueous suspension containing glycerin, microcrystalline cellulose and carboxymethylcellulose sodium, phenylethyl alcohol (2.5 mg/g), edetate disodium, benzalkonium chloride (0.1 ...Azelastine is an antihistamine that works by blocking certain natural substances called histamines that are responsible for allergic symptoms. Fluticasone belongs to a class of drugs known as corticosteroids. 137 μg of azelastine hydrochloride and 50 μg of fluticasone propionate. The dosing regimen is one spray per nostril twice daily, for a total daily dose of 548 μg of azelastine Azelastine is an antihistamine. It is commonly used to treat allergy symptoms. It comes as a nasal spray (intranasal) to treat symptoms such as runny, itchy, and stuffy nose and sneezing. This is sold under the brand name Astelin®. Azelastine also comes in eye drop form to treat itchy eyes due to allergies.There are 253 drugs known to interact with azelastine/fluticasone nasal, along with 5 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 29 are major, 222 are moderate, and 2 are minor. Both of these nasal sprays contain a steroid (e.g., fluticasone or mometasone) and an antihistamine (e.g., azelastine or olopatadine). When compared to steroid nasal sprays, antihistamine nasal sprays might work faster — but antihistamine sprays are not more effective at treating your allergies. However, the combination of medications may be ...Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings. burning, dry, or itching eyes. change in sense of smell. changes in vision. discharge or excessive tearing. hives or welts. irritation at the application site. loss of smell. mental or mood changes.Oct 28, 2022 · Dymista (Azelastine And Fluticasone Nasal) received an overall rating of 10 out of 10 stars from 5 reviews. See what others have said about Dymista (Azelastine And Fluticasone Nasal), including the effectiveness, ease of use and side effects. This medicine may increase your risk of having some unwanted effects in the nose. Check with your doctor right away if you or your child have bloody mucus, sores inside the nose, unexplained nosebleeds, or a whistling sound when you breathe while you are using this medicine. You may get infections more easily while you are using this medicine.Azelastine is an antihistamine that works by blocking certain natural substances called histamines that are responsible for allergic symptoms. Fluticasone belongs to a class of drugs known as corticosteroids.Aug 1, 2022 · Both of these nasal sprays contain a steroid (e.g., fluticasone or mometasone) and an antihistamine (e.g., azelastine or olopatadine). When compared to steroid nasal sprays, antihistamine nasal sprays might work faster — but antihistamine sprays are not more effective at treating your allergies. However, the combination of medications may be ... There are 253 drugs known to interact with azelastine/fluticasone nasal, along with 5 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 29 are major, 222 are moderate, and 2 are minor.The article by Ratner et al1 regarding combination therapy with azelastine and fluticasone nasal sprays for allergic rhinitis clearly demonstrates that by day 4 of therapy combination treatment is superior to either agent used alone in improving nasal symptoms. By day 12 of therapy, however, although combination therapy remained statistically significantly superior to azelastine alone ... Due to different primary mechanisms of action, the combination product of azelastine and fluticasone was hypothesized to have a potential for greater efficacy than with each agent alone. 2.2.2 What are the proposed dosage and routes of administration? MP29-02 is to be administered intra-nasally at the proposed dose of 1 spray per nostril AZELASTINE; FLUTICASONE (a ZEL as teen; floo TIK a sone) treats allergy symptoms such as sneezing, itching, or runny or stuffy nose. It works by blocking histamine, a substance released by the body during an allergic reaction. It also works by decreasing inflammation in the nose, making it easier to breathe.Find medical information for azelastine/fluticasone propionate nasal on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures.Azelastine is an antihistamine that works by blocking certain natural substances called histamines that are responsible for allergic symptoms. Fluticasone belongs to a class of drugs known as corticosteroids.Azelastine is an antihistamine that works by blocking certain natural substances called histamines that are responsible for allergic symptoms. Fluticasone belongs to a class of drugs known as... n. Known hypersensitivity to azelastine hydrochloride, fluticasone propionate, similar drugs, or any of the active ingredients . 6. The protocol should include a list of the prescription and over-the-counter drug products, procedures, and activities that are prohibited during the study, such as antihistamines,Apr 16, 2019 · To evaluate the effectiveness of azelastine-fluticasone nasal spray (AzeFlu), study authors systematically searched the PubMed, EMBASE, Cochrane, and MEDLINE databases for randomized controlled trials comparing patient-reported symptom scores in adults and children receiving combination therapy vs azelastine, fluticasone, or placebo. Patient ... Dec 5, 2022 · Dymista nasal spray contains a combination of azelastine and fluticasone. Azelastine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Fluticasone is a steroid that prevents the release of substances in the body that cause ... Ratings & Reviews. Azelastine / fluticasone nasal has an average rating of 5.7 out of 10 from a total of 153 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 40% reported a negative effect. Be the first to share your experience with this drug. View all 153 reviews. Review this drug.Dymista (azelastine / fluticasone) is a combination medication containing azelastine and fluticasone. It works well to treat seasonal allergies for adults and children 6 years and older, especially if allergies don't improve with nasal steroid medications alone.See full list on mayoclinic.org AZELASTINE; FLUTICASONE treats allergy symptoms such as sneezing, itching, or runny or stuffy nose.It works by blocking histamine, a substance released by the body during an allergic reaction.The only combination treatment, which comprises azelastine hydrochloride and fluticasone propionate, so far in a single advanced delivery system has proven its efficacy and safety in clinical trials of adult patients with AR. Objective: To critically review and identify gaps in the existing data for children in all different strata of pediatric ...Nasonex (mometasone furoate monohydrate) Nasal Spray and Dymista (azelastine hydrochloride and fluticasone propionate) are used to treat nasal symptoms such as congestion, sneezing, and runny nose caused by seasonal or year-round allergies. Nasonex Nasal Spray is also used to treat nasal polyps in adults. Nasonex and Dymista both contain steroids.Oct 28, 2022 · Dymista (Azelastine And Fluticasone Nasal) received an overall rating of 10 out of 10 stars from 5 reviews. See what others have said about Dymista (Azelastine And Fluticasone Nasal), including the effectiveness, ease of use and side effects. Azelastine is an antihistamine that works by blocking certain natural substances called histamines that are responsible for allergic symptoms. Fluticasone belongs to a class of drugs known as...Objective: Combination therapy with intranasal azelastine and fluticasone propionate is an option for treatment of allergic rhinitis. This systematic review and meta-analysis examines existing literature to determine efficacy in treating allergic rhinitis compared to monotherapy. years of age and older who require treatment with both azelastine hydrochloride and fluticasone propionate for symptomatic relief. (1.1) DOSAGE AND ADMINISTRATION •Recommended dos age: 1 spray per nostril twice daily (2.1) •For intranasal use only. (2.2) •Prime before initial use and when it has not been used for 14 or more days. (2.2) Sep 1, 2014 · Generic fluticasone (Flonase) remains the BCF choice. UF and step preferred drugs are generic fluticasone (Flonase), and the generics for flunisolide, azelastine 137 mcg, and ipratropium. Nasonex is now Non Formulary; the price per inhaler will increase to $76.96 (FSS price). To maximize cost Jun 5, 2023 · Azelastine–fluticasone has been successfully used since 10 years as recently evidenced . This combination and its peculiar formulation produce interesting additive effects: rapid onset of action, already since 15', potent anti-inflammatory action, improving olfaction impairment, and biophysical characteristics, including large spray volume ... Jun 30, 2023 · Introduction. MP-AzeFlu Nasal Spray consists of a fixed-dose combination of azelastine hydrochloride (AZE) and fluticasone propionate (FLU) that is used for the relief of symptoms of moderate to severe seasonal (SAR) and perennial allergic rhinitis (PAR). 1,2 Due to different primary mechanisms of action of the individual agents, MP-AzeFlu nasal spray provides greater efficacy than therapy ... In clinical trials, Dymista was superior to azelastine nasal spray, fluticasone nasal spray, and placebo in providing symptom relief. Dymista was approved by the FDA in May, 2012. Dymista is the brand name for azelastine hydrochloride and fluticasone propionate. Dymista is not available in generic form. You need a prescription for Dymista. Drugs and Supplements Azelastine And Fluticasone (Nasal Route) Proper Use Drug information provided by: Merative, Micromedex ® Use this medicine only as directed. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of side effects. This medicine comes with patient information leaflet.Pharmacodynamics. Azelastine antagonizes the actions of histamine, resulting in the relief of histamine-mediated allergy symptoms. 2,10,11 Onset of action occurs within 15 minutes with intranasal formulations and as quickly as 3 minutes with ophthalmic solutions. 1 Intranasal formulations have a relatively long-duration of action, with peak effects observed 4-6 hours after the initial dose and ...
Astepro (azelastine), which blocks histamine. NasalCrom (cromolyn sodium), which stabilizes mast cells. Antihistamine nasal sprays work quickly — within 15 minutes. Nasalcrom takes longer, providing relief in about 1 to 2 weeks. Both can be used to both treat and prevent symptoms. OTC decongestant nasal sprays. De5az
AZELASTINE; FLUTICASONE treats allergy symptoms such as sneezing, itching, or runny or stuffy nose. It works by blocking histamine, a substance released by the body during an allergic reaction. It also works by decreasing inflammation in the nose, making it easier to breathe. It is a combination of an antihistamine and a steroid.Azelastine / fluticasone nasal User Reviews & Ratings. Brand names: Dymista. Azelastine / fluticasone nasal has an average rating of 5.7 out of 10 from a total of 145 reviews on Drugs.com. 47% of reviewers reported a positive experience, while 40% reported a negative experience. Condition. Azelastine / fluticasone nasal Pregnancy Warnings. This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus. Animal studies have not been conducted with the combination product, but have been conducted with both active ingredients individually. Animal azelastine studies have revealed evidence of fetal harm ...In clinical trials, Dymista was superior to azelastine nasal spray, fluticasone nasal spray, and placebo in providing symptom relief. Dymista was approved by the FDA in May, 2012. Dymista is the brand name for azelastine hydrochloride and fluticasone propionate. Dymista is not available in generic form. You need a prescription for Dymista. Aug 3, 2023 · What is azelastine nasal? Azelastine nasal (for the nose) is an antihistamine that is used to treat sneezing, runny or stuffy nose, itching, and other nasal symptoms of allergies. Azelastine nasal is for use in adults and children at least 6 years old. Azelastine nasal may also be used for purposes not listed in this medication guide. Dược lực học: Azelastine + Fluticasone chứa Azelastine hydrocortisone và fluticasone propionate. Mỗi thành phần có cơ chế tác dụng khác nhau và tạo tác dụng hiệp đồng để cải thiện các triệu chứng của viêm mũi và viêm giác mạc dị ứng. Hỗn dịch xịt mũi chứa azelastine ...Analyte(s) to measure (in appropriate biological fluid): Fluticasone propionate and azelastine in plasma Equivalence based on: AUC and C max for fluticasone propionate and azelastine. The 90% confidence intervals for the geometric mean T/R ratios of baseline-corrected AUC and C max should fall within the limits of 80.00-125.00% Find medical information for azelastine/fluticasone propionate nasal on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures. Dec 5, 2022 · Dymista nasal spray contains a combination of azelastine and fluticasone. Azelastine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Fluticasone is a steroid that prevents the release of substances in the body that cause ... Inhaled corticosteroids (applies to azelastine/fluticasone nasal) hyperadrenocorticism. Moderate Potential Hazard, Moderate plausibility. The use of inhaled and nasal corticosteroids may rarely precipitate or aggravate conditions of hyperadrenocorticism. Although adverse effects of corticosteroids may be minimized by local rather than systemic ...Active Ingredients: Azelastine hydrochloride; Fluticasone propionate . Dosage Form; Route: Spray, metered; Nasal . Strength: 0.137 mg/spray; 0.05 mg/spray. Recommended Studies: Two options: (1) eight in vitro bioequivalence studies, or (2) six in vitro bioequivalence studies, one in vivo bioequivalence study with .